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Kintor’s Covid Drug Candidate Cuts Hospital, Death Risk

Results came from a multi-national clinical trial with over 700 subjects across the world, mostly in the US, recruited from April-December 2021, who were given proxalutamide or a placebo


China covid
China has approved Pfizer's Paxlovid and Brii Biosciences's antibody-based medicine for mild and moderate Covid patients with high risk of progressing to severe conditions. Photo: CNSphoto via Reuters.

 

China’s Kintor Pharmaceutical said on Wednesday its potential Covid-19 treatment proxalutamide effectively reduced the risk of hospitalisation and death in a clinical trial involving outpatients with mild to moderate symptoms.

The results came from a multi-national clinical trial with over 700 subjects across the world, mostly from the United States, recruited during April-December 2021, who were given either proxalutamide or a placebo, the company said in a filing.

It remains unclear how many patients contracted the Omicron variant.

Among trial subjects with more than seven days of treatment, six in the placebo group were hospitalised, including one death, versus no death or hospitalisation in the group taking proxalutamide, according to the filing, without providing detailed data.

For all subjects who took at least one day of treatment, proxalutamide reduced the risk of hospitalisation or death by 50%. For subjects with more than one day of treatment, the risk was reduced by 71%, Kintor said.

China has approved Pfizer’s Paxlovid and Brii Biosciences’s antibody-based medicine for mild and moderate Covid-19 patients with high risk of progressing to severe conditions.

Kintor’s chairman, Tong Youzhi, said a separate trial of the treatment for use in severe cases is facing some challenges, as the number of such cases remain low in China, and the trial in Ukraine has been affected by the ongoing war with Russia.

Kintor is arranging sites in countries including Southeast Asian nations to push forward the trial, he said.

 

 

  • Reuters with additional editing by Jim Pollard

 

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Jim Pollard

Jim Pollard is an Australian journalist based in Thailand since 1999. He worked for News Ltd papers in Sydney, Perth, London and Melbourne before travelling through SE Asia in the late 90s. He was a senior editor at The Nation for 17+ years and has a family in Bangkok.